Adiphenine hydrochloride

Research use only, not for human use.

Adiphenine hydrochloride is a nicotinic receptor inhibitor, used as an antispasmodic drug.

Adiphenine hydrochloride is a nicotinic receptor inhibitor, used as an antispasmodic drug.(In Vitro):Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC50 of 1.9 μM.Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC50 of 1.8 μM.Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC50s of 3.7 and 6.3 μM, respectively.Adiphenine (50-200 μM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.(In Vivo):Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED50 of 62 mg/kg in mice.

Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC50 of 1.9 μM.Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC50 of 1.8 μM.Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC50s of 3.7 and 6.3 μM, respectively.Adiphenine (50-200 μM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.

Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED50 of 62 mg/kg in mice.

Adiphenine hydrochloride | NSC 129224 | NSC-129224 | NSC129224

Endocrinology/Hormones

AChR

Nicotinic Receptor

Neurological Disease

——

50-42-0

347.88

C20H25NO2·HCl

>98% (HPLC)

Ethanol: 18 mg/mL (51.74 mM); Water: 70 mg/mL (201.21 mM); DMSO: 30 mg/mL (86.23 mM)

O=C(OCCN(CC)CC)C(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl

Acetic acid, diphenyl-, 2-(diethylamino)ethyl ester, hydrochloride

(-20℃)

With Ice Pack

≥ 2 years